I have been looking forward to give this a try for a while, however due to the extremely high prices of these cables today, I have been unable to get my hands on one of them until now. This is the setup I have used: VirtualBox VM with Windows 98 SE installed Latest release of the Adaptec ASPI drivers installed - https://storage.microsemi.com/en-us/speed/software_pc/aspi/aspi_471a2_exe.php USBXchange Cable with its drivers for Windows 98 Installed - https://storage.microsemi.com/en-us/support/_eol/scsi_mac/usbxchange/ Katana SDK R10.1 installed All other standard items for the Dev.Box such as VGA cable, Dreamcast Controller, etc. While I must admit the VM was struggling to detect the cable during the first few attempts, I managed to make it work several times by executing the following steps in order: Connect the USBXchange to the Dev.Box and to the PC hosting the VM Power on the Dev.Box Launch the Windows 98 SE VM Eventually, Windows 98 SE will detect the USBXchange as connected and you would be able to perform a connectivity test with the help of DA-Check. I have not tested with other Windows OS or directly with a physical machine hosting Windows 98 SE but I'm confident I should work if you stick to an OS for which you can find the right drivers for your cable. There is number of cables out there, some more expensive than others. If you manage to find one of these cables for a decent price, it's a good way to get rid of the old bulky physical setup we are all used to. Now at least you know USBXchange works with this configuration - and potentially beyond.